Activities of cholic acid-derived antimicrobial agents against multidrug-resistant bacteria.
نویسندگان
چکیده
Cationic cholic acid derivatives displayed potent and broad-spectrum activity against multidrug-resistant Gram-negative and -positive bacteria. Specific examples were effective permeabilizers of the outer membranes of many strains of multidrug-resistant Gram-negative bacteria and sensitized these to hydrophobic antibiotics. We also prepared a new cholic acid derivative with improved apparent selectivity for prokaryote membranes.
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عنوان ژورنال:
- The Journal of antimicrobial chemotherapy
دوره 47 5 شماره
صفحات -
تاریخ انتشار 2001